Biomimetic polymeric transcatheter heart valve leaflets with low calcification and good regenerative ability

Author:

Wang Xiaoxiao1,Jiang Honghui1,Zhang Wenjie2,Kong Yuanyuan1,Kong Deling13ORCID,Liu Jing14,Wang Zhihong1ORCID

Affiliation:

1. Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, 236 Baidi Road, Nankai district, Tianjin 300192, China

2. Tianjin Center for Medical Device Evaluation and Inspection, Tianjin, China

3. Key Laboratory of Bioactive Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, College of Life Science, Nankai University, Tianjin 300071, China

4. Tianjin Enterprise Key Laboratory for Application Research of Hyaluronic Acid, Tianjin 300385, China

Abstract

Transcatheter aortic valve replacement (TAVR) technology is quickly advancing in clinic, however, as it expands to low-risk populations and younger patients (age <65 years), device durability is becoming a major challenge.

Funder

National Natural Science Foundation of China

Science Fund for Distinguished Young Scholars of Tianjin

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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