Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ring
Author:
Affiliation:
1. Institute of Organic Chemistry and Biochemistry
2. Academy of Sciences of the Czech Republic
3. 166 10 Prague 6
4. Czech Republic
5. The School of Chemistry and Molecular Biosciences
6. The University of Queensland
7. Brisbane
8. Australia
Abstract
Novel phosphonate nucleotides were synthesized. An inhibitor of the P. falciparum HGXPRT with a Ki of 0.6 μM was found.
Funder
Czech Science Foundation
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00097A
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4. Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates
5. Synthesis of pyrrolidin-1-yl analogues of pyrimidine dideoxynucleosides
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