Proline cis–trans isomerization and its implications for the dimerization of analogues of cyclopeptide stylostatin 1: a combined computational and experimental study-Reference-Cited by-同舟云学术

Proline cis–trans isomerization and its implications for the dimerization of analogues of cyclopeptide stylostatin 1: a combined computational and experimental study

Published:2016 Issue:18 Volume:18 Page:12755-12767
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

López-Martínez C.¹²³⁴⁵,Flores-Morales P.⁶⁷⁸⁹¹⁰,Cruz M.¹²³⁴⁵,González T.¹¹¹²¹³⁴⁵,Feliz M.¹¹¹²¹³⁴⁵,Diez A.¹²³⁴⁵,Campanera Josep M.¹⁴²³⁴⁵

Affiliation:

1. Laboratori de Química Orgànica and Institut de Biomedicina (IBUB)

2. Facultat de Farmàcia

3. Universitat de Barcelona

4. 08028 Barcelona

5. Spain

6. Departamento de Polímeros

7. Facultad de Ciencias Químicas

8. Universidad de Concepción

9. Concepción

10. Chile

11. NMR Facility

12. Scientific and Technical Centers

13. University of Barcelona

14. Departament de Fisicoquimica and Institut de Biomedicina (IBUB)

Abstract

Derivatives of the cyclic heptapeptide stylostatin 1 exhibit acis–transconformational equilibrium modulated by the hydrogen bond network.

Funder

Ministerio de Ciencia e Innovación

Agència de Gestió d’Ajuts Universitaris i de Recerca

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CP/C5CP05937B

Reference57 articles.

1. How proteins bind macrocycles

2. Lead discovery and optimization strategies for peptide macrocycles

3. The exploration of macrocycles for drug discovery — an underexploited structural class

4. Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery

5. Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance

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