Phomopsischalins A–C, polycyclic-fused cytochalasins from the endophytic fungus <i>Phomopsis</i> sp. shj2 and their abilities to induce lysosomal function-Reference-Cited by-同舟云学术

Phomopsischalins A–C, polycyclic-fused cytochalasins from the endophytic fungus Phomopsis sp. shj2 and their abilities to induce lysosomal function

Published:2023 Issue:9 Volume:10 Page:2218-2225
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Chen Rong¹^ORCID,Guo Li-Jing²,Li Xue-Dan²,Li Xing-Ren¹,Hu Kun¹,Tang Jian-Wei¹,Ye Zhen-Nan²^ORCID,Yan Bing-Chao¹^ORCID,Puno Pema-Tenzin¹^ORCID

Affiliation:

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

2. Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China

Abstract

Phomopsischalins A−C (1–3), two classes of polycyclic-fused cytochalasins, were discovered from Phomopsis sp. shj2. Compound 2 is the first example of a cytochalasin accelerating lysosome function in a transcription factor EB-independent manner.

Funder

Chinese Academy of Sciences

National Natural Science Foundation of China

Yunnan Provincial Science and Technology Department

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO00252G

Reference21 articles.

1. Protein kinase C controls lysosome biogenesis independently of mTORC1