Isatin-based spiro indolenine alkaloids from <i>Isatis indigotica</i> Fortune with anti-neuroinflammatory and acetylcholinesterase inhibitory effects-Reference-Cited by-同舟云学术

Isatin-based spiro indolenine alkaloids from Isatis indigotica Fortune with anti-neuroinflammatory and acetylcholinesterase inhibitory effects

Published:2024 Issue:2 Volume:11 Page:427-436
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Bai Ming¹^ORCID,Xi Yu-Fei¹,Mi Si-Hui¹,Yang Pei-Yuan¹,Lou Li-Li¹,Lv Tian-Ming¹,Zhang Xin¹,Yao Guo-Dong¹,Lin Bin²,Huang Xiao-Xiao¹³^ORCID,Song Shao-Jiang¹^ORCID

Affiliation:

1. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China

2. Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China

3. State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, Jiangsu 222001, China

Abstract

Compounds 1a/1b are a pair of enantiomers characterized by an unprecedented 6/5/6/5/6 N,O-heterocyclic scaffold with a unique spiro[4.5] core. Compound 2 is the first 6/5/6/5/5/6 hexacyclic skeleton fused with an unexpected dispiro[4.4.0.4] system.

Funder

China Postdoctoral Science Foundation

Scientific Research Fund of Liaoning Provincial Education Department

Liaoning Revitalization Talents Program

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D3QO01769A

Reference42 articles.

1. Recent advances in spirocyclization of indole derivatives

2. Natural spirocyclic alkaloids and polyphenols as multi target dementia leads

3. Bioactive spiropyrrolizidine oxindole alkaloid enantiomers from Isatis indigotica Fortune

4. Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

5. Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery