α-Branched amines through radical coupling with 2-azaallyl anions, redox active esters and alkenes-Reference-Cited by-同舟云学术

α-Branched amines through radical coupling with 2-azaallyl anions, redox active esters and alkenes

Published:2022 Issue:13 Volume:13 Page:3740-3747
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Duan Shengzu¹,Zi Yujin¹,Wang Lingling¹,Cong Jielun¹,Chen Wen¹^ORCID,Li Minyan²,Zhang Hongbin¹^ORCID,Yang Xiaodong¹^ORCID,Walsh Patrick J.²^ORCID

Affiliation:

1. Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan Province Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China

2. Roy and Diana Vagelos Laboratories Penn/Merck Laboratory for High-Throughput Experimentation Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA, USA

Abstract

A mild method for the construction of α-branched amine derivatives is presented. SET processes between the Ni catalyst, redox active esters and 2-azaallyl anions generate azaallyl radicals and alkyl radicals that functionalize the alkenes.

Funder

National Natural Science Foundation of China

National Science Foundation

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC00500J

Reference93 articles.

1. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals