Efficient construction of functionalized pyrroloindolines through cascade radical cyclization/intermolecular coupling-Reference-Cited by-同舟云学术

Efficient construction of functionalized pyrroloindolines through cascade radical cyclization/intermolecular coupling

Published:2024 Issue:6 Volume:15 Page:2205-2210
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Jiang Yonggang¹,Liu Dongxiang¹,Zhang Lening¹,Qin Cuirong¹,Li Hui¹,Yang Haitao¹,Walsh Patrick J.²^ORCID,Yang Xiaodong¹^ORCID

Affiliation:

1. Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Pharmacy, Yunnan University, Kunming 650091, P. R. China

2. Roy and Diana Vagelos Laboratories, Penn/Merck Laboratory for High-Throughput Experimentation, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, USA

Abstract

A novel tandem radical cyclization/intermolecular coupling between 2-azaallyl anions and indole N-aryloxy acetamides is developed, which enables the synthesis of C3a-substituted pyrroloindolines under mild conditions.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC05210A

Reference50 articles.

1. Privileged scaffolds for library design and drug discovery

2. Heterocyclic chemistry in crop protection

3. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

4. Sketching the historical development of pyrimidones as the inhibitors of the HIV integrase

5. Mycobacterium Tuberculosis (MTB) GyrB inhibitors: An attractive approach for developing novel drugs against TB

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1. Recent Advances in Radical Coupling Strategies Enabled by 2‐Azaallyl Anions as Super‐Electron‐Donors;Advanced Synthesis & Catalysis;2024-02-27

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