A facile synthesis of 2-exo-methylenepenam; a potent intermediate for syntheses of new β-lactamase inhibitors
Author:
Publisher
Royal Society of Chemistry (RSC)
Subject
Molecular Medicine
Link
http://pubs.rsc.org/en/content/articlepdf/1992/C3/C39920001793
Reference11 articles.
1. Penicillin resistance: the chemistry of .beta.-lactamase inhibition
2. Synthesis and .beta.-lactamase inhibitory properties of 2.beta.-(chloromethyl)-2.alpha.-methylpenam-3.alpha.-carboxylic acid 1,1-dioxide
3. Comparative evaluation of a new beta-lactamase inhibitor, YTR 830, combined with different beta-lactam antibiotics against bacteria harboring known beta-lactamases
4. Preparation of 2-exomethylene penam and penicillin-2-carboxylate systems
5. A convenient synthesis of 2-exo-methylene penam, a potent intermediate for new β-lactam antibiotics synthesis
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1. Metal- and nonmetal-catalyzed synthesis of five-membered S,N-heterocycles;Journal of Sulfur Chemistry;2017-12-23
2. ChemInform Abstract: A Facile Synthesis of 2-exo-Methylenepenam. A Potent Intermediate for Syntheses of New β-Lactamase Inhibitors.;ChemInform;2010-08-20
3. Recent Advances of Bismuth(III) Salts in Organic Chemistry: Application to the Synthesis of Heterocycles of Pharmaceutical Interest;Current Organic Synthesis;2009-11-01
4. Enantiospecific synthesis of substituted 1-norbornyl trifluoromethanethiosulfonates and 1-norbornanethiols;Tetrahedron: Asymmetry;1997-09
5. Synthesis of 2-exo-Methylenepenam and 3-Chloro-Δ3-cephem through a Sequential Reductive 1,2-Elimination/S−S Bond Fission or Chloride Ion-Addition/Cyclization of 3,4-Disubstituted 2-Butenoates in Metal Salt/Metal Combinations;The Journal of Organic Chemistry;1997-05-01
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