STEP: profiling cellular-specific targets and pathways of bioactive small molecules in tissues <i>via</i> integrating single-cell transcriptomics and chemoproteomics-Reference-Cited by-同舟云学术

STEP: profiling cellular-specific targets and pathways of bioactive small molecules in tissues via integrating single-cell transcriptomics and chemoproteomics

Published:2024 Issue:12 Volume:15 Page:4313-4321
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Chen Jiayun¹,Chu Zheng¹,Zhang Qian²,Wang Chen¹,Luo Piao²,Zhang Ying¹,Xia Fei¹^ORCID,Gu Liwei¹^ORCID,Wong Yin Kwan³,Shi Qiaoli¹,Xu Chengchao¹,Tang Huan¹,Wang Jigang¹²³⁴^ORCID

Affiliation:

1. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China

2. School of Traditional Chinese Medicine and School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China

3. Department of Nephrology, Shenzhen Key Laboratory of Kidney Diseases, Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People's Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, China

4. State Key Laboratory of Antiviral Drugs, School of Pharmacy, Henan University, Kaifeng 475004, China

Abstract

STEP: single-cell target profiling, an integrated pipeline for profiling cellular-specific targets of active small molecules in tissues.

Funder

National Key Research and Development Program of China

China Academy of Chinese Medical Sciences

Science and Technology Foundation of Shenzhen City

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC04826H