A robust MRI contrast agent for specific display of the interstitial stream

Author:

Zhou Xiaohan12ORCID,Cheng Junwei3,He Fangfei13,Ao Zhuo12,Zhang Peisen3,Wang Jing4,Li Qing5,Tang Weinan16,Zhou Yiyan7,Liang Yan12,Hou Yi3ORCID,Liu Wentao12ORCID,Han Dong12ORCID

Affiliation:

1. CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China

2. University of Chinese Academy of Sciences, Beijing 100139, China

3. College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China

4. Center for Medical Device Evaluation, NMPA, Beijing 100081, China

5. Department of Nutrition, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China

6. Beijing Wandong Medical Technology Co., Beijing 100015, China

7. College of Biological Sciences, University of California at Davis, Sacramento, CA, 95817, USA

Abstract

PAA is modified by DTPA pre-chelation with Gd-based monomers to generate an MRI CA with a highr1and nanoscale diameter, introducing PAA-Gd, then appliedviainterstitial space injection to show interstitial stream. The path to kidneys is depicted.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

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