Convergent chemoenzymatic synthesis of <i>O</i>-GalNAc rare cores 5, 7, 8 and their sialylated forms-Reference-Cited by-同舟云学术

Convergent chemoenzymatic synthesis of O-GalNAc rare cores 5, 7, 8 and their sialylated forms

Published:2023 Issue:7 Volume:14 Page:1837-1843
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Gadi Madhusudhan Reddy¹,Chen Congcong¹²,Bao Shumin¹,Wang Shuaishuai¹^ORCID,Guo Yuxi¹,Han Jinghua¹,Xiao Weidong³,Li Lei¹^ORCID

Affiliation:

1. Department of Chemistry and Center for Diagnostics & Therapeutics, Georgia State University, Atlanta, GA 30303, USA

2. Shandong Academy of Pharmaceutical Science, Key Laboratory of Biopharmaceuticals, Engineering Laboratory of Polysaccharide Drugs, National-Local Joint Engineering Laboratory of Polysaccharide Drugs, Jinan 250101, China

3. Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA

Abstract

Mucin rare cores 5, 7, and 8 with 1,2-cis glycosidic bonds were prepared with exclusive stereo-selectivity from a versatile precursor. Enzyme-catalyzed regio-selective sialylation was then achieved, yielding natural sialylated rare cores.

Funder

National Institute of General Medical Sciences

National Heart, Lung, and Blood Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D2SC06925C

Reference51 articles.

1. Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology

2. Mucins and Pathogenic Mucin-Like Molecules Are Immunomodulators During Infection and Targets for Diagnostics and Vaccines