Highly stereoselective α-glycosylation with GalN<sub>3</sub> donors enabled collective synthesis of mucin-related tumor associated carbohydrate antigens-Reference-Cited by-同舟云学术

Highly stereoselective α-glycosylation with GalN₃ donors enabled collective synthesis of mucin-related tumor associated carbohydrate antigens

Published:2024 Issue:17 Volume:15 Page:6552-6561
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Shou Kunxiu¹,Zhang Yunqin¹,Ji Yujie²,Liu Bin¹^ORCID,Zhou Qingli¹,Tan Qiang¹,Li Fuying³,Wang Xiufang³,Lu Gang²^ORCID,Xiao Guozhi¹^ORCID

Affiliation:

1. State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 132 Lanhei Road, Kunming, 650201, China

2. School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, 250100, China

3. Department of Chemistry, Kunming University, 2 Puxing Road, Kunming, 650214, China

Abstract

Collective synthesis of mucin-related tumor associated carbohydrate antigens has been achieved via this new α-glycosylation method with GalN3 donors, which features mild conditions, broad substrate scope, high yields and stereoselectivities.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Yunnan Province

Yunnan Provincial Science and Technology Department

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC01348D

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