Multi-scale modeling of folic acid-functionalized TiO<sub>2</sub> nanoparticles for active targeting of tumor cells-Reference-Cited by-同舟云学术

Multi-scale modeling of folic acid-functionalized TiO₂ nanoparticles for active targeting of tumor cells

Published:2022 Issue:33 Volume:14 Page:12099-12116
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Donadoni Edoardo¹,Siani Paulo¹,Frigerio Giulia¹,Di Valentin Cristiana¹²^ORCID

Affiliation:

1. Dipartimento di Scienza dei Materiali, Università di Milano-Bicocca, via R. Cozzi 55, 20125 Milano, Italy

2. BioNanoMedicine Center NANOMIB, University of Milano-Bicocca, Italy

Abstract

We computationally design and characterize bare and PEGylated TiO2 nanoparticles decorated with folic acid (FA) to target cancer cells. The FA exposure to the solvent and FA–FA interactions play a key role for the nanoconjugates' clinical efficacy.

Funder

Università degli Studi di Milano-Bicocca

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NR/D2NR02603A

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