The effect of polymer coating on nanoparticles’ interaction with lipid membranes studied by coarse-grained molecular dynamics simulations-Reference-Cited by-同舟云学术

The effect of polymer coating on nanoparticles’ interaction with lipid membranes studied by coarse-grained molecular dynamics simulations

Published:2024 Issue:18 Volume:16 Page:9108-9122
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Donadoni Edoardo¹²^ORCID,Siani Paulo¹,Frigerio Giulia¹^ORCID,Milani Carolina¹,Cui Qiang²^ORCID,Di Valentin Cristiana¹³^ORCID

Affiliation:

1. Department of Materials Science, University of Milano-Bicocca, via R. Cozzi 55, 20125 Milan, Italy

2. Department of Chemistry, Boston University, 590 Commonwealth Ave, Boston, MA 02215, USA

3. BioNanoMedicine Center NANOMIB, University of Milano-Bicocca, Italy

Abstract

By coarse-grained molecular dynamics simulations, we have unveiled that nanoparticles coated with mixed hydrophobic/hydrophilic polymer chains spontaneously penetrate lipid membranes, unlike those covered with chains of hydrophilic character only.

Funder

European Commission

Università degli Studi di Milano-Bicocca

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NR/D4NR00495G

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