Reactivity of kiteplatin with S-donor biomolecules and nucleotides-Reference-Cited by-同舟云学术

Reactivity of kiteplatin with S-donor biomolecules and nucleotides

Published:2014 Issue:34 Volume:43 Page:12851-12859
ISSN:1477-9226
Container-title:Dalton Trans.
language:en
Short-container-title:Dalton Trans.

Author:

Petruzzella Emanuele¹²³⁴⁵,Margiotta Nicola⁴⁵⁶,Natile Giovanni⁴⁵⁶,Hoeschele James D.¹²³

Affiliation:

1. Chemistry Department

2. Eastern Michigan University

3. Ypsilanti, USA

4. Dipartimento di Chimica

5. Università degli Studi di Bari Aldo Moro

6. 70125 Bari, Italy

Abstract

Interaction of kiteplatin with S-donors is investigated. Kiteplatin–glutathione adducts can further react with 5′-GMP in presence of O₂. This unique reaction may account for its activity toward oxaliplatin-resistant colon cancer.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/DT/C4DT01474J

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