Synthesis of a novel series of 2,3,4-trisubstituted oxazolidines designed by isosteric replacement or rigidification of the structure and cytotoxic evaluation-Reference-Cited by-同舟云学术

Synthesis of a novel series of 2,3,4-trisubstituted oxazolidines designed by isosteric replacement or rigidification of the structure and cytotoxic evaluation

Published:2014 Issue:11 Volume:5 Page:1693-1699
ISSN:2040-2503
Container-title:Med. Chem. Commun.
language:en
Short-container-title:Med. Chem. Commun.

Author:

Andrade Saulo F.¹²³⁴⁵,Teixeira Claudia S.¹²³⁴,Ramos Jonas P.⁶⁷³⁸,Lopes Marcela S.¹²³⁴,Pádua Rodrigo M.¹²³⁴,Oliveira Mônica C.¹²³⁴,Souza-Fagundes Elaine M.⁶⁷³⁸,Alves Ricardo J.¹²³⁴

Affiliation:

1. Departamento de Produtos Farmacêuticos

2. Faculdade de Farmácia

3. Universidade Federal de Minas Gerais (UFMG)

4. Belo Horizonte, Brazil

5. Departamento de Produção de Matéria-Prima

6. Departamento de Fisiologia e Biofísica

7. Instituto de Ciências Biológicas

8. Brazil

Abstract

Rigidification of the structure of 2,3,4-trisubstituted oxazolidines enhances the activity against LNCaP cells without affecting normal cell proliferation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C4MD00136B

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