Structure-Based Design and Synthesis of Potent, Ethylenediamine-Based, Mammalian Farnesyltransferase Inhibitors as Anticancer Agents-Reference-Cited by-同舟云学术

Structure-Based Design and Synthesis of Potent, Ethylenediamine-Based, Mammalian Farnesyltransferase Inhibitors as Anticancer Agents

Published:2010-09-07 Issue:19 Volume:53 Page:6867-6888
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Fletcher Steven¹,Keaney Erin Pusateri¹,Cummings Christopher G.¹,Blaskovich Michelle A.²,Hast Michael A.³,Glenn Matthew P.¹,Chang Sung-Youn¹,Bucher Cynthia J.²,Floyd Ryan J.²,Katt William P.¹,Gelb Michael H.⁴,Van Voorhis Wesley C.⁵,Beese Lorena S.³,Sebti Said M.²,Hamilton Andrew D.¹

Affiliation:

1. Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06511

2. Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute and Department of Molecular Medicine, University of South Florida, Tampa, Florida 33612

3. Department of Biochemistry, Duke University Medical Center, Box 3711, Durham, North Carolina 27710

4. Department of Chemistry and Biochemistry

5. Department of Medicine

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm1001748

Reference41 articles.

1. Thematic review series: Lipid Posttranslational Modifications. Farnesyl transferase inhibitors

2. Inhibitors of Farnesyltransferase: A Rational Approach to Cancer Chemotherapy?

3. Understanding Ras: ‘it ain’t over ’til it’s over’

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