A targeted approach for the synthesis of multi-phosphorylated peptides: a tool for studying the role of phosphorylation patterns in proteins-Reference-Cited by-同舟云学术

A targeted approach for the synthesis of multi-phosphorylated peptides: a tool for studying the role of phosphorylation patterns in proteins

Published:2019 Issue:42 Volume:17 Page:9284-9290
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Samarasimhareddy Mamidi¹²³⁴,Mayer Daniel⁵⁶⁷⁸⁹,Metanis Norman¹²³⁴^ORCID,Veprintsev Dmitry⁵⁶⁷⁸⁹,Hurevich Mattan¹²³⁴^ORCID,Friedler Assaf¹²³⁴^ORCID

Affiliation:

1. Institute of Chemistry

2. The Hebrew University of Jerusalem

3. Jerusalem 91904

4. Israel

5. Laboratory of Biomolecular Research

6. Paul Scherrer Institute

7. 5232 Villigen PSI

8. Switzerland and Department of Biology

9. ETH Zürich

Abstract

An efficient strategy for the synthesis of multiphosphorylated peptides is described. Such peptides are essential in elucidating the biological roles of the phosphorylation patterns and barcodes.

Funder

Israel Science Foundation

Israel Cancer Research Fund

European Commission

Lady Davis Fellowship Trust, Hebrew University of Jerusalem

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01874C

Reference50 articles.

1. The origins of protein phosphorylation

2. The regulation of protein phosphorylation

3. The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)

4. The Chemical Biology of Protein Phosphorylation

5. Phosphorylation in Protein-Protein Binding: Effect on Stability and Function

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