Rapid flow-based synthesis of post-translationally modified peptides and proteins: a case study on MYC's transactivation domain-Reference-Cited by-同舟云学术

Rapid flow-based synthesis of post-translationally modified peptides and proteins: a case study on MYC's transactivation domain

Published:2024 Issue:23 Volume:15 Page:8756-8765
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Williams Elyse T.¹^ORCID,Schiefelbein Kevin¹^ORCID,Schuster Matthias¹^ORCID,Ahmed Ikhlas M. M.²^ORCID,De Vries Marije²,Beveridge Rebecca²^ORCID,Zerbe Oliver¹^ORCID,Hartrampf Nina¹^ORCID

Affiliation:

1. Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland

2. Department for Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral St, Glasgow G1 1XL, UK

Abstract

Automated flow peptide synthesis (AFPS) gives access to peptides and proteins with post-translational modifications (PTMs) and enables investigation of PTM-mediated regulation, and was used to study the PTM-dependence of the MYC:Bin1 interaction.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

University of Strathclyde

Universität Zürich

Dr. Helmut Legerlotz-Stiftung

UK Research and Innovation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC00481G

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