Synthesis of 3-acyltetramates by side chain manipulation and their antibacterial activity-Reference-Cited by-同舟云学术

Synthesis of 3-acyltetramates by side chain manipulation and their antibacterial activity

Published:2014 Issue:11 Volume:12 Page:1711-1716
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Tan Song Wei Benjamin¹²³⁴⁵,Chai Christina L. L.⁵⁶⁷⁸⁹,Moloney Mark G.¹²³⁴

Affiliation:

1. The Department of Chemistry

2. Chemistry Research Laboratory

3. The University of Oxford

4. Oxford OX1 3TA, UK

5. Institute of Chemical and Engineering Sciences (ICES)

6. Singapore 138665, Singapore

7. Department of Pharmacy

8. National University of Singapore

9. Singapore, Singapore

Abstract

An efficient approach for the introduction of 3-acyl side chain groups onto a core tetramate system, which are suitable for further manipulation by nucleophilic displacement or Horner–Wadsworth–Emmons coupling, provides access to a diverse library of substituted tetramates related to two distinct classes of natural products, equisetin and pramanicin.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00095A

Reference49 articles.

1. Naturally Occurring Tetramic Acids: Structure, Isolation, and Synthesis

2. Tetramic and tetronic acids: An update on new derivatives and biological aspects

3. Structure-Activity Relationships of Precursors and Analogs of Natural 3-Enoyl-tetramic Acids

4. Equisetin and a novel opposite stereochemical homolog phomasetin, two fungal metabolites as inhibitors of HIV-1 integrase

5. Synthesis of the Antibiotic (R)-Reutericyclinvia Dieckmann Condensation

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