The design, synthesis and biological evaluation of novel thiamin diphosphate analog inhibitors against the pyruvate dehydrogenase multienzyme complex E1 from Escherichia coli
Author:
Affiliation:
1. Key Laboratory of Pesticide & Chemical Biology (CCNU)
2. Ministry of Education
3. College of Chemistry
4. Central China Normal University
5. Wuhan 430079, China
6. College of Life Science
Abstract
Optimal binding mode for the novel potent inhibitor 4j against PDHc-E1 from E. coli.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB01347F
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4. In vitro activity of β-lactam and non–β-lactam antibiotics in extended-spectrum β-lactamase–producing clinical isolates of Escherichia coli
5. Regulation of thiamin diphosphate-dependent 2-oxo acid decarboxylases by substrate and thiamin diphosphate.Mg(II) – evidence for tertiary and quaternary interactions
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