Dissecting the reaction of Phase II metabolites of ibuprofen and other NSAIDS with human plasma protein-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Dissecting the reaction of Phase II metabolites of ibuprofen and other NSAIDS with human plasma protein

Published:2014 Issue:10 Volume:5 Page:3789-3794
ISSN:2041-6520
Container-title:Chem. Sci.
language:en
Short-container-title:Chem. Sci.

Author:

Monrad Rune Nygaard¹²³⁴,Errey James C.¹²³⁴,Barry Conor S.¹²³⁴,Iqbal Mazhar⁵²⁶⁷,Meng Xiaoli⁵²⁶⁷,Iddon Lisa⁵²⁶⁷,Perrie Jennifer A.⁵²⁶⁷,Harding John R.⁸⁹¹⁰,Wilson Ian D.⁸⁹¹⁰,Stachulski Andrew V.⁵²⁶⁷,Davis Benjamin G.¹²³⁴

Affiliation:

1. Chemistry Research Laboratory

2. Department of Chemistry

3. University of Oxford

4. Oxford, UK

5. The Robert Robinson Laboratories

6. University of Liverpool

7. Liverpool, UK

8. Drug Metabolism and Pharmacokinetics

9. Astra Zeneca

10. Cheshire SK10 4TG, UK

Abstract

Blood-protein transacylation/glycosylation reactivity of glucuronides may distinguish beneficial (e.g., ibuprofen) and toxic (e.g., ibufenac) drugs.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/SC/C4SC01329H

Reference46 articles.

1. Acyl Glucuronides Revisited: Is the Glucuronidation Proces a Toxification as Well as a Detoxification Mechanism?

2. US FDA , Guidance for Industry: Safety testing of Drug metabolites, Center for Drug Evaluation and Research, Rockville, MD, USA, 2008

3. Proteins identified as targets of the acyl glucuronide metabolite of mycophenolic acid in kidney tissue from mycophenolate mofetil treated rats

4. Acyl glucuronides: the good, the bad and the ugly

5. NMR Spectroscopic Studies on the in Vitro Acyl Glucuronide Migration Kinetics of Ibuprofen ((±)-(R,S)-2-(4-Isobutylphenyl) Propanoic Acid), Its Metabolites, and Analogues

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Transacylation and hydrolysis of the acyl glucuronides of ibuprofen and its α-methyl-substituted analogues investigated by 1H NMR spectroscopy and computational chemistry: Implications for drug design;Journal of Pharmaceutical and Biomedical Analysis;2024-08

2. Minimizing the DILI potential of carboxylic acid-containing drugs: a perspective;Medicinal Chemistry Research;2023-09

3. A review of the synthesis, bioanalysis, and chemical reactivity of xenobiotic acyl-coenzyme a thioesters;Medicinal Chemistry Research;2023-08-10

4. Preclinical evaluation of chemically reactive metabolites and mitigation of bioactivation in drug discovery;Drug Discovery Today;2023-07

5. Preclinical Metabolism and Disposition of TP0473292, a Novel Oral Prodrug of the Potent Metabotropic Glutamate 2/3 Receptor Antagonist TP0178894 for the Treatment of Depression;Drug Metabolism and Disposition;2023-02-08

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号京ICP备18003416号-3