1. Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington, London SW7 2AZ, U.K., Department of Drug Metabolism and Pharmacokinetics, AstraZeneca, Macclesfield, Cheshire SK 10 4TG, U.K., and Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, U.K.