Different positions of amide side chains on the benzimidazo[1,2-a]quinoline skeleton strongly influence biological activity

Author:

Perin Nataša12345ORCID,Alić Jasna12345ORCID,Liekens Sandra6789,Van Aerschot Arthur61089,Vervaeke Peter111289ORCID,Gadakh Bharat61089,Hranjec Marijana12345ORCID

Affiliation:

1. Department of Organic Chemistry

2. Faculty of Chemical Engineering and Technology

3. University of Zagreb

4. HR-10000 Zagreb

5. Croatia

6. Rega Institute

7. Department of Microbiology and Immunology

8. B-3000 Leuven

9. Belgium

10. Department of Pharmaceutical and Pharmacological Sciences

11. Rega Institute for Medical Research

12. Laboratory of Virology and Chemotherapy

Abstract

Benzimidazo[1,2-a]quinolines substituted with amide chains have been evaluated for their antiproliferative, antibacterial and antiviral activity in vitro.

Funder

Hrvatska Zaklada za Znanost

Fonds Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Reference26 articles.

1. R. B. Silverman , The Organic Chemistry of Drug Design and Drug Action , Elsevier Academic Press , 2nd edn, 2004

2. M. Demeunynck , C.Bailly and W. D.Wilson , In D.N.A. and R.N.A. Binders , Wiley-VCH , Weinheim , 2002

3. The therapeutic journey of benzimidazoles: A review

4. Design and synthesis of N1-aryl-benzimidazoles 2-substituted as novel HIV-1 non-nucleoside reverse transcriptase inhibitors

5. Antimicrobial Activities of Some Tetrahydronaphthalene-Benzimidazole Derivatives

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