Simple inorganic base promoted polycyclic construction using mucohalic acid as a C3 synthon: synthesis and AIE probe application of benzo[4,5]imidazo[1,2-a]pyridines

Author:

Yang Kai12,Chen Zhi-Xi2,Zhou Yong-Jun1,Chen Qi1,Yu Shi-Wei1,Luo Shi-He1ORCID,Wang Zhao-Yang1ORCID

Affiliation:

1. School of Chemistry, South China Normal University, Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, Guangzhou 510006, P. R. China

2. College of pharmacy, Gannan Medical University, Ganzhou 341000, P. R. China

Abstract

Using mucohalic acid as C3 synthon via a transition metal-free multicomponent reaction, an eco-friendly protocol to synthesize C1-functionalized benzo[4,5]imidazo[1,2-a]pyridines which can be applied as fluorescence probe for picric acid is described.

Funder

Basic and Applied Basic Research Foundation of Guangdong Province

Education Department of Jiangxi Province

Gannan Medical University

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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