Highly efficient H2S scavengers via thiolysis of positively-charged NBD amines

Author:

Ismail Ismail12345ORCID,Chen Zhuoyue678910,Sun Lu1112131410ORCID,Ji Xiuru1112131410,Ye Haishun678910,Kang Xueying678910,Huang Haojie678910,Song Haibin12345,Bolton Sarah G.1516171819,Xi Zhen12345,Pluth Michael D.1516171819ORCID,Yi Long678910ORCID

Affiliation:

1. State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology

2. College of Chemistry

3. National Pesticide Engineering Research Center

4. Collaborative Innovation Center of Chemical Science and Engineering

5. Nankai University

6. State Key Laboratory of Organic–Inorganic Composites

7. Beijing Key Lab of Bioprocess

8. Beijing University of Chemical Technology (BUCT)

9. Beijing 100029

10. China

11. Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics)

12. School of Pharmacy

13. Tianjin Medical University

14. Tianjin 300070

15. Department of Chemistry and Biochemistry

16. Materials Science Institute

17. Knight Campus for Accelerating Scientific Impact

18. Institute of Molecular Biology

19. University of Oregon

Abstract

We demonstrate that positively-charged NBD amines can effectively scavenge biological H2S in live cells and in mice.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Beijing Municipality

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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