Benign synthesis of fused-thiazoles with enone-based natural products and drugs for lead discovery

Author:

Alnufaie Rawan12345,Ali Mohamad Akbar678910ORCID,Alkhaibari Ibrahim S.12345,Roy Subrata12345,Day Victor W.61112135,Alam Mohammad A.12345ORCID

Affiliation:

1. Department of Chemistry and Physics

2. College of Science and Mathematics

3. Arkansas State University

4. Jonesboro

5. USA

6. Department of Chemistry

7. College of Science

8. King Faisal University

9. Al-Ahsa 31982

10. Saudi Arabia

11. Integrated Science Building

12. University of Kansas

13. Lawrence

Abstract

In an effort to synthesize a library of bioactive molecules, we present an efficient synthesis of fused-thiazole derivatives of natural products and approved drugs by using an environmentally usable solvent, acetic acid, and without any external reagent.

Funder

University of Arkansas for Medical Sciences

National Institute of General Medical Sciences

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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