Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801-Reference-Cited by-同舟云学术

Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801

Published:2019 Issue:12 Volume:10 Page:2118-2125
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Domingo Riyad¹²³⁴,van der Westhuyzen Renier¹²³⁴,Hamann Anton R.¹²³⁴,Mostert Konrad J.¹²³⁴,Barnard Leanne¹²³⁴,Paquet Tanya¹²³⁴,Tjhin Erick T.⁵⁶⁷⁸^ORCID,Saliba Kevin J.⁵⁶⁷⁸⁹^ORCID,van Otterlo Willem A. L.¹⁰²³⁴^ORCID,Strauss Erick¹²³⁴^ORCID

Affiliation:

1. Department of Biochemistry

2. Stellenbosch University

3. Matieland 7602

4. South Africa

5. Research School of Biology

6. The Australian National University

7. Canberra

8. Australia

9. Medical School

10. Department of Chemistry and Polymer Science

Abstract

Presenting an optimised synthesis of the fungus-derived antibiotic CJ-15,801 which shows selective activity against Staphylococcus aureus and Plasmodium falciparum.

Funder

National Institute of Allergy and Infectious Diseases

National Research Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00312F

Reference25 articles.

1. Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development

2. Coenzyme A biosynthesis: an antimicrobial drug target