Rapid synthesis of spirodienones <i>via</i> electrochemical dearomative spirocyclization in flow-Reference-Cited by-同舟云学术

Rapid synthesis of spirodienones via electrochemical dearomative spirocyclization in flow

Published:2022 Issue:23 Volume:9 Page:6586-6591
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Li Nan¹,Shi Zhaojiang¹^ORCID,Yuan Yaofeng¹^ORCID,Li Zhen²^ORCID,Ye Ke-Yin¹^ORCID

Affiliation:

1. Institute of Pharmaceutical Science and Technology, College of Chemistry, Fuzhou University, Fuzhou 350108, China

2. Institute of Molecular Aggregation Science, Tianjin University, Tianjin 300072, China

Abstract

An electrochemical dearomative spirocyclization in flow has been developed, featuring the use of electrons as the clean oxidant in a minimum amount of electrolytes to afford diverse spirodienones in a short reaction time.

Funder

Fuzhou University

State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO01392D

Reference70 articles.

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5. The use of spirocyclic scaffolds in drug discovery

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