Rapid and complete paraffin removal from human tissue sections delivers enhanced Raman spectroscopic and histopathological analysis-Reference-Cited by-同舟云学术

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Rapid and complete paraffin removal from human tissue sections delivers enhanced Raman spectroscopic and histopathological analysis

Published:2020 Issue:4 Volume:145 Page:1499-1510
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Gaifulina Riana¹²³⁴²,Caruana Daren J.⁴²³,Oukrif Dahmane⁵²³,Guppy Naomi J.⁶⁷³,Culley Siân¹²³⁸²,Brown Robert⁹¹⁰³,Bell Ian⁹¹⁰³,Rodriguez-Justo Manuel¹¹¹²¹³³,Lau Katherine⁹¹⁰³,Thomas Geraint M. H.¹²³^ORCID

Affiliation:

1. Department of Cell and Developmental Biology

2. University College London

3. UK

4. Department of Chemistry

5. Research Department of Pathology

6. UCL Advanced Diagnostics

7. University College Hospital

8. MRC Laboratory for Molecular Cell Biology

9. Spectroscopy Products Division

10. Renishaw plc

11. Department of Gastrointestinal Pathology

12. University College Hospital and Department of Research Pathology/Cancer Institute

13. UCL

Abstract

A simple method completely removes contaminating paraffin from samples for clinical Raman and enhanced immunohistological analysis.

Funder

Renishaw

Medical Research Council

UCLH Biomedical Research Centre

Wellcome Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/AN/C9AN01030K

Reference28 articles.

1. Raman spectroscopy for medical diagnostics — From in-vitro biofluid assays to in-vivo cancer detection

2. Evaluation of the suitability of ex vivo handled ovarian tissues for optical diagnosis by Raman microspectroscopy

3. Raman microspectroscopy for the early detection of pre-malignant changes in cervical tissue

4. Spectral histopathology of colon cancer tissue sections by Raman imaging with 532 nm excitation provides label free annotation of lymphocytes, erythrocytes and proliferating nuclei of cancer cells

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