Sensitivity of VCD spectroscopy for small structural and stereochemical changes of macrolide antibiotics

Author:

Demarque Daniel P.12345ORCID,Heinrich Sascha16745ORCID,Schulz Frank16745ORCID,Merten Christian12345ORCID

Affiliation:

1. Ruhr-Universität Bochum

2. Organische Chemie 2

3. Stereochemistry and Chiroptical Spectroscopy

4. 44801 Bochum

5. Germany

6. Organische Chemie 1

7. Natural Products Chemistry

Abstract

Despite the large and flexible structure of erythromycin and its derivatives, VCD spectroscopy is shown to be sensitive to various structural changes including chemical changes and epimerizations of single stereocenters.

Funder

Deutsche Forschungsgemeinschaft

Alexander von Humboldt-Stiftung

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Reference43 articles.

1. W. F. Reynolds , in Pharmacognosy , ed. S. Badal and R. Delgoda , Academic Press , Boston , 2017 , pp. 567–596

2. Current Strategies for the Elucidation of the Structures of Natural Products

3. A. Williams , et al. , Modern NMR Approaches to the Structure Elucidation of Natural Products: Data Acquisition and Applications to Compound Classes , The Royal Society of Chemistry , 2017 , vol. 2

4. Fragmentation reactions using electrospray ionization mass spectrometry: an important tool for the structural elucidation and characterization of synthetic and natural products

5. Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons

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