Amyloid-β peptide 37, 38 and 40 individually and cooperatively inhibit amyloid-β 42 aggregation

Author:

Braun Gabriel A.1ORCID,Dear Alexander J.1234ORCID,Sanagavarapu Kalyani1,Zetterberg Henrik5678,Linse Sara1ORCID

Affiliation:

1. Biochemistry and Structural Biology, Lund University, Lund, Sweden

2. Department of Cell Biology, Harvard Medical School, Boston, MA, USA

3. Paulson School of Engineering and Applied Science, Harvard University, Cambridge, MA, USA

4. Department of Chemistry, University of Cambridge, Cambridge, UK

5. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden

6. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden

7. Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK

8. UK Dementia Research Institute at UCL, London, UK

Abstract

The pathology of Alzheimer's disease is connected to the aggregation of β-amyloid (Aβ) peptide, which in vivo exists as a number of length-variants. This study identifies the Aβ37/38/40 ratio that is maximally inhibitory to Aβ42 aggregation.

Funder

Vetenskapsrådet

H2020 European Research Council

Novo Nordisk Fonden

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Reference74 articles.

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5. The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

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