Evaluation of ligand-based NMR screening methods to characterize small molecule binding to HIV-1 glycoprotein-41
Author:
Affiliation:
1. Department of Basic Sciences
2. Touro University-California
3. Vallejo
4. USA
5. Department of Pharmaceutical Chemistry
Abstract
STD NMR pinpoints the binding mode of a small ligand in the hydrophobic pocket of gp41.
Funder
National Institute of Allergy and Infectious Diseases
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB00954B
Reference48 articles.
1. HIV Entry and Envelope Glycoprotein-mediated Fusion
2. The HIV Env-mediated fusion reaction
3. HIV-1 gp41 Six-Helix Bundle Formation Occurs Rapidly after the Engagement of gp120 by CXCR4 in the HIV-1 Env-Mediated Fusion Process
4. Evidence That the Transition of HIV-1 Gp41 into a Six-Helix Bundle, Not the Bundle Configuration, Induces Membrane Fusion
5. Kinetic Dependence to HIV-1 Entry Inhibition
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