Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing-Reference-Cited by-同舟云学术

Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing

Published:2020-05-04 Issue:19 Volume:142 Page:8706-8727
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Chen Jonathan L.¹^ORCID,Zhang Peiyuan¹,Abe Masahito¹,Aikawa Haruo¹,Zhang Liying²,Frank Alexander J.³,Zembryski Timothy³,Hubbs Christopher¹,Park HaJeung¹,Withka Jane²,Steppan Claire⁴,Rogers Lucy⁴,Cabral Shawn⁴,Pettersson Martin²,Wager Travis T.²,Fountain Matthew A.³,Rumbaugh Gavin¹,Childs-Disney Jessica L.¹,Disney Matthew D.¹^ORCID

Affiliation:

1. Department of Chemistry and Neuroscience, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States

2. Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States

3. Department of Chemistry & Biochemistry, State University of New York at Fredonia, 311 Science Center, Fredonia, New York 14063, United States

4. Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States

Funder

National Institute of Neurological Disorders and Stroke

NIH Office of the Director

Pfizer

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.0c00768

Reference79 articles.

1. Non-coding RNA

2. The spliceosome: a novel multi-faceted target for therapy

3. Results from a phase 1 study of nusinersen (ISIS-SMNRx) in children with spinal muscular atrophy

4. Targeting RNA with Small-Molecule Drugs: Therapeutic Promise and Chemical Challenges

5. Targeting RNA with Small Molecules To Capture Opportunities at the Intersection of Chemistry, Biology, and Medicine

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