Synthesis of fluorinated carbocyclic pyrimidine nucleoside analogues-Reference-Cited by-同舟云学术

Synthesis of fluorinated carbocyclic pyrimidine nucleoside analogues

Published:2022 Issue:47 Volume:20 Page:9469-9489
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Benckendorff Caecilie M. M.¹²,Slyusarchuk Valentyna D.²,Huang Ningwu³,Lima Marcelo A.¹^ORCID,Smith Mark³,Miller Gavin J.¹²^ORCID

Affiliation:

1. Centre for Glycosciences, Keele University, Keele, Staffordshire, ST5 5BG, UK

2. Lennard-Jones Laboratory, School of Chemical and Physical Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK

3. Riboscience LLC, 428 Oakmead Pkwy, Sunnyvale, CA 94085, USA

Abstract

Synthesis of 6′-fluorinated carbauridine scaffolds enables access to related cytidine, ProTide and 2′-deoxy analogues, alongside preliminary exploration of their biological capabilities in cancer cell viability assays.

Funder

Keele University

Royal Society of Chemistry

UK Research and Innovation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01761J

Reference42 articles.

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