Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19-Reference-Cited by-同舟云学术

Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19

Published:2021-10-29 Issue:12 Volume:7 Page:1980-1985
ISSN:2374-7943
Container-title:ACS Central Science
language:en
Short-container-title:ACS Cent. Sci.

Author:

McIntosh John A.¹^ORCID,Benkovics Tamas¹,Silverman Steven M.¹^ORCID,Huffman Mark A.¹,Kong Jongrock¹,Maligres Peter E.¹^ORCID,Itoh Tetsuji¹,Yang Hao¹,Verma Deeptak¹^ORCID,Pan Weilan¹,Ho Hsing-I¹,Vroom Jonathan²,Knight Anders M.²,Hurtak Jessica A.²,Klapars Artis¹,Fryszkowska Anna¹^ORCID,Morris William J.¹^ORCID,Strotman Neil A.¹^ORCID,Murphy Grant S.¹,Maloney Kevin M.¹^ORCID,Fier Patrick S.¹^ORCID

Affiliation:

1. Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Codexis, Inc., 200 Penobscot Drive, Redwood City, California 94063, United States

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscentsci.1c00608

Reference29 articles.

1. WHO Coronavirus Disease (COVID-19) Dashboard. https://covid19.who.int/ accessed Oct 12th, 2021.

2. Wibmer, C. K.; Ayres, F.; Hermanus, T.; Madzivhandila, M.; Kgagudi, P.; Lambson, B. E.; Vermeulen, M.; van den Berg, K.; Rossouw, T.; Boswell, M.; Ueckermann, V.; Meiring, S.; von Gottberg, A.; Cohen, C.; Morris, L.; Bhiman, J. N.; Moore, P. L. SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma. BioRxiv 2021.