Molecular chirality mediated amyloid formation on phospholipid surfaces

Author:

Wang Xue12,Wang Cunli2,Chu Huiying3,Qin Haijuan4,Wang Dongdong2,Xu Feifei2,Ai Xuanjun2,Quan Chunshan5,Li Guohui3,Qing Guangyan2ORCID

Affiliation:

1. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, P. R. China

2. Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, P. R. China

3. Laboratory of Molecular Modeling and Design, State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, P. R. China

4. Research Centre of Modern Analytical Technology, Tianjin University of Science and Technology, Tianjin 300457, P. R. China

5. College of Life Science, Dalian Minzu University, Dalian 116600, P. R. China

Abstract

A remarkable inhibition effect and chiral discrimination are observed when the amyloid peptide aggregates on chiral phospholipid surfaces.

Funder

National Natural Science Foundation of China

Dalian Institute of Chemical Physics

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Reference84 articles.

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2. Alzheimer's disease

3. C.Patterson , World Alzheimer report 2018: the state of the art of dementia research: new frontiers , Alzheimer's Disease International , London , 2018

4. Protein Misfolding, Functional Amyloid, and Human Disease

5. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

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