Route exploration and synthesis of the reported pyridone-based PDI inhibitor STK076545-Reference-Cited by-同舟云学术

Route exploration and synthesis of the reported pyridone-based PDI inhibitor STK076545

Published:2020 Issue:34 Volume:18 Page:6665-6681
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Greve Eric¹²³⁴,Lindeman Sergey V.¹²³⁴,Scartelli Christina⁵⁶⁷⁸⁹,Lin Lin⁵⁶⁷⁸⁹,Flaumenhaft Robert⁵⁶⁷⁸⁹,Dockendorff Chris¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Marquette University

3. Milwaukee

4. USA

5. Division of Hemostasis and Thrombosis

6. Department of Medicine

7. Beth Israel Deaconess Medical Center

8. Harvard Medical School

9. Boston

Abstract

A 5-step synthesis of a reported PDI inhibitor was developed using an aldol reaction with an allyl ester. Conventional approaches for preparing β-keto amides with a pyridone in the alpha position were complicated by undesired fragmentations or rearrangements.

Funder

Foundation for Women's Wellness

Arthur J. Schmitt Foundation

Marquette University

National Heart, Lung, and Blood Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB01205J

Reference46 articles.