A ‘soft spot’ for drug transport: modulation of cell stiffness using fatty acids and its impact on drug transport in lung model-Reference-Cited by-同舟云学术

A ‘soft spot’ for drug transport: modulation of cell stiffness using fatty acids and its impact on drug transport in lung model

Published:2015 Issue:13 Volume:3 Page:2583-2589
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Haghi Mehra¹²³⁴⁵,Traini Daniela¹²³⁴⁵,Wood Lisa G.⁶⁷³,Oliver Brian¹²³⁸⁹,Young Paul M.¹²³⁴⁵,Chrzanowski Wojciech¹⁰²³¹¹¹²

Affiliation:

1. Woolcock Institute of Medical Research

2. The University of Sydney

3. Australia

4. Discipline of Pharmacology

5. Faculty of Medicine

6. Centre for Asthma and Respiratory Diseases

7. Hunter Medical Research Institute and The University of Newcastle

8. School of Medical & Molecular Biosciences

9. University of Technology Sydney

10. Faculty of Pharmacy

11. Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Centre for Regenerative Medicine

12. Dankook University

Abstract

The impact of a polyunsaturated fatty acid, arachidonic acid (AA), on membrane fluidity of epithelial cells and subsequent modulation of the drug transport was investigated.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2015/TB/C4TB01928H

Reference32 articles.

1. The Biochemistry of n-3 Polyunsaturated Fatty Acids

2. A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma

3. Single-cell force spectroscopy

4. Connection between biomechanics and cytoskeleton structure of lymphocyte and Jurkat cells: An AFM study

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