Kinetic modelling of acyl glucuronide and glucoside reactivity and development of structure–property relationships-Reference-Cited by-同舟云学术

Kinetic modelling of acyl glucuronide and glucoside reactivity and development of structure–property relationships

Published:2020 Issue:7 Volume:18 Page:1389-1401
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Bradshaw Peter R.¹²³⁴⁵^ORCID,Richards Selena E.⁶⁷⁸⁹^ORCID,Wilson Ian D.¹²³⁴⁵,Stachulski Andrew V.⁶¹⁰¹¹¹²¹³,Lindon John C.¹²³⁴⁵^ORCID,Athersuch Toby J.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Metabolism

2. Digestion and Reproduction

3. Faculty of Medicine

4. Imperial College London

5. London

6. Department of Chemistry

7. Khalifa University of Science and Technology

8. Abu Dhabi

9. United Arab Emirates

10. The Robert Robinson Laboratories

11. University of Liverpool

12. Liverpool L69 7ZD

13. UK

Abstract

Detailed kinetic and transition structure modelling to rationalise the differences in reactivity observed between the acyl glucuronide and glucoside metabolites of a series of phenylacetic acid analogues.

Funder

Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/C9OB02008J

Reference72 articles.

1. Acyl glucuronides: the good, the bad and the ugly

2. Acyl glucuronide metabolites: Implications for drug safety assessment

3. Properties of Acyl Glucuronides: Implications for Studies of the Pharmacokinetics and Metabolism of Acidic Drugs