Driving to a Better Understanding of Acyl Glucuronide Transformations Using NMR and Molecular Modeling-Reference-Cited by-同舟云学术

Driving to a Better Understanding of Acyl Glucuronide Transformations Using NMR and Molecular Modeling

Published:2022-02-14 Issue:3 Volume:35 Page:459-474
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Buevich Alexei V.¹^ORCID,He Cyndi Qixin²^ORCID,Pio Barbara³,Samuel Koppara⁴,Mitra Kaushik⁴^ORCID,Sherer Edward C.¹^ORCID,Cancilla Mark T.⁴,Chobanian Harry R.⁴

Affiliation:

1. Process and Analytical Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

2. Computational and Structural Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

3. Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

4. Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.1c00366

Reference47 articles.

1. Acyl Glucuronides: Biological Activity, Chemical Reactivity, and Chemical Synthesis

2. RCS Drug Discovery Series No. 1;Kalgutkar A. S.,2010

3. Toxicity of Carboxylic Acid-Containing Drugs: The Role of Acyl Migration and CoA Conjugation Investigated

4. Correlation between glucuronidation and covalent adducts formation with proteins of nonsteroidal anti-inflammatory drugs

5. Acyl Glucuronide Drug Metabolites: Toxicological and Analytical Implications

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Transacylation and hydrolysis of the acyl glucuronides of ibuprofen and its α-methyl-substituted analogues investigated by 1H NMR spectroscopy and computational chemistry: Implications for drug design;Journal of Pharmaceutical and Biomedical Analysis;2024-08

2. Acyl glucuronides–mediators of drug-induced toxicities?;Medicinal Chemistry Research;2023-04-24

3. Acyl Glucuronide and Coenzyme A Thioester Metabolites of Carboxylic Acid-Containing Drug Molecules: Layering Chemistry with Reactive Metabolism and Toxicology;Chemical Research in Toxicology;2022-10-06

4. ¹⁸O-Enabled High-Throughput Acyl Glucuronide Stability Assay;Chemical Research in Toxicology;2022-07-14