1. Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, U.K., Drug Metabolism and Pharmacokinetics Department, AstraZeneca U.K. Ltd., Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K., Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K., and Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3GE, U.K.