A new entry to highly functionalized pyrroles via a cascade reaction of α-amino esters and alkynals-Reference-Cited by-同舟云学术

A new entry to highly functionalized pyrroles via a cascade reaction of α-amino esters and alkynals

Published:2020 Issue:67 Volume:56 Page:9691-9694
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Wei Liang¹²³⁴⁵,Xu Shi-Ming¹²³⁴⁵,Jia Ziqi¹²³⁴⁵,Tao Hai-Yan¹²³⁴⁵,Wang Chun-Jiang¹²³⁴⁵^ORCID

Affiliation:

1. Engineering Research Center of Organosilicon Compounds & Materials

2. Ministry of Education

3. College of Chemistry and Molecular Sciences

4. Wuhan University

5. Wuhan 430072

Abstract

Here, we developed an expedient access route to highly functionalized pyrroles from readily available α-amino acid ester hydrochlorides and alkynals via a cascade condensation/intramolecular cyclization followed by a unique C–N ester migration process. A variety of 1,2,3-trisubstituted pyrroles were successfully prepared in good yields under mild conditions.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Project 211

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC02964E

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