Practical Synthesis of Pharmaceutically Relevant Pyrroles from α,β‐Unsaturated Aldehydes and Phenacyl Azides

Abstract

AbstractStructurally diverse pyrroles were synthesized by direct coupling of α, β‐unsaturated aldehydes and phenacyl azides. The scope of the synthetic method was successfully demonstrated by synthesizing 28 different phenyl(5‐phenyl‐1H‐pyrrol‐2‐yl)methanones in high yields (87–95 %). Derivatization of a few synthesized pyrroles was demonstrated which shows the potential application of the developed protocol in new functional materials. To get a mechanistic insight of the reaction, a typical reaction was performed in a deuterated solvent and the progress of the reaction was monitored by recording its 1H NMR at regular time intervals.