(3 + 2)-Annulation of 1,3-N,Si-tetraorganosilane reagents TsHNCH2SiBnR1R2 with arynes for efficient synthesis of 3-silaindolines-Reference-Cited by-同舟云学术

(3 + 2)-Annulation of 1,3-N,Si-tetraorganosilane reagents TsHNCH₂SiBnR¹R² with arynes for efficient synthesis of 3-silaindolines

Published:2022 Issue:20 Volume:9 Page:5453-5462
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Cui Deyun¹,Feng Ying¹,Gan Yu²,Yin Jiaqi²,Wang Wanshu¹,Fan Yu¹,Gao Lu¹,Ke Bowen²,Song Zhenlei¹^ORCID

Affiliation:

1. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China

2. Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan university, Chengdu, 610041, China

Abstract

1,3-N,Si-Tetraorganosilane reagents TsHNCH2SiBnR1R2 were developed as robust synthons to prepare 3-silaindolines via a Cs2CO3-promoted (3 + 2)-annulation reaction with arynes.

Funder

National Natural Science Foundation of China

Department of Science and Technology of Sichuan Province

West China Hospital, Sichuan University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO01075E

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1. Synthetic Approaches for the Construction of Five- and Six-Membered Silaazacycles