Improving the anticancer activity of platinum(iv) prodrugs using a dual-targeting strategy with a dichloroacetate axial ligand-Reference-Cited by-同舟云学术

Improving the anticancer activity of platinum(iv) prodrugs using a dual-targeting strategy with a dichloroacetate axial ligand

Published:2019 Issue:39 Volume:9 Page:22240-22247
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Liu Fengfan¹²³⁴⁵,Dong Xiaomei¹²³⁴⁵,Shi Qiwen¹²³⁴⁵,Chen Jianli¹²³⁴⁵,Su Weike¹²³⁴⁵^ORCID

Affiliation:

1. National Engineering Research Center for Process Decelopment of Active Pharmaceutial Ingredients

2. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals

3. Zhejiang University of Technology

4. Hangzhou

5. P. R. China

Abstract

Complex 1b could release complex B and DCA, playing a dual-targeting anti-tumor effect against cancer cells, targeting nuclear DNA and mitochondria, respectively.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA03690C

Reference31 articles.

1. A Drug of Such Damned Nature.1 Challenges and Opportunities in Translational Platinum Drug Research

2. The status of platinum anticancer drugs in the clinic and in clinical trials

3. Picazoplatin, an Azide-Containing Platinum(II) Derivative for Target Analysis by Click Chemistry

4. Progress in the Development of Preventative Drugs for Cisplatin-Induced Hearing Loss

5. The side effects of platinum-based chemotherapy drugs: a review for chemists

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