Simultaneous determination of Avanafil and Dapoxetine in human plasma using liquid chromatography/tandem mass spectrometry (LC-MS/MS) based on a protein precipitation technique

Author:

Abou-Omar Mona N.1,Annadi Abdelaziz M.2,El Zahar Noha M.34,Youssef Ahmed. O.2,Amin Mohammed A.5ORCID,Attia Mohamed S.2ORCID,Mohamed Ekram H.6

Affiliation:

1. Department of Chemistry, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt

2. Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt

3. Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Organization of African Unity Street, Abassia, Cairo 11566, Egypt

4. Medicinal Chemistry Department, Faculty of Pharmacy, King Salman International University, Ras-Sedr, South Sinai, Egypt

5. Department of Chemistry, College of Science, Taif University, P.O. BOX 11099, Taif 21944, Saudi Arabia

6. Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British University in Egypt, 11837, El Sherouk City, Cairo, Egypt

Abstract

A rapid and selective LC-MS/MS method is described for the simultaneous assay of Avanafil and Dapoxetine in human plasma via a protein precipitation (PP) sample preparation technique.

Funder

Taif University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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