Synthesis, characterization, and radioprotective activity of α,β-unsaturated aryl sulfone analogs and their Tempol conjugates-Reference-Cited by-同舟云学术

Synthesis, characterization, and radioprotective activity of α,β-unsaturated aryl sulfone analogs and their Tempol conjugates

Published:2017 Issue:5 Volume:8 Page:1063-1068
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Zhou Nan¹²³⁴⁵,Feng Tian¹²³⁴⁵,Shen Xin¹²³⁴⁵,Cui Jiahui¹²³⁴⁵,Wu Rangxin¹²³⁴⁵,Wang Libin¹²³⁴⁵,Wang Siwang¹²³⁴⁵,Zhang Shengyong¹²³⁴⁵,Chen Hui¹²³⁴⁵^ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. School of Pharmacy

3. Fourth Military Medical University

4. Xi'an 710032

5. China

Abstract

Some novel α,β-unsaturated aromatic sulfone analogs and Tempol conjugates are prepared and evaluated for their radioprotective activity, revealing that the agents have both prophylactic and mitigation effects against radiation damage.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00017K

Reference13 articles.

1. Reported Radiation Overexposure Accidents Worldwide, 1980-2013: A Systematic Review

2. Gamma radiation induces growth retardation, impaired egg production, and oxidative stress in the marine copepod Paracyclopina nana

3. Radiprotective effect of abana, a polyherbal drug following total body irradiation

4. A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.)

5. Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response

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