Affiliation:
1. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China
Abstract
Abstract
The hematopoietic system is sensitive to radiation. In this research, new aryl sulfone derivatives (XH-201 and XH-202) containing a nitrogen heterocycle were designed and synthesized and their radio-protective efficacies with regard to the hematopoietic system were evaluated. XH-201 administration significantly increased the survival rate of mice after 8.0 Gy total body irradiation (TBI). The results showed that XH-201 treatment not only increased the white blood cells, platelets counts and the percentage of hematopoietic progenitor cells and hematopoietic stem cells in mice exposed to 4.0 Gy TBI but also decreased DNA damage, as determined by flow cytometric analysis of histone H2AX phosphorylation. In addition, our data demonstrated that XH-201 decreased the mitochondrial reactive oxygen species (ROS) levels in hematopoietic cells. Overall, these data suggest that XH-201 is beneficial for the protection of the hemoatopoietic system against radiation-induced injuries.
Funder
CAMS Innovation Fund for Medical Science
Chinese Academy of Medical Sciences
Peking Union Medical College
Key Scientific and Technological Support Projects of Tianjin Key R&D Program
Tianjin Major Scientific and Technological Projects of New Drug Creation
China Postdoctoral Science Foundation
National Natural Science Foundation of China
Publisher
Oxford University Press (OUP)
Subject
Health, Toxicology and Mutagenesis,Radiology, Nuclear Medicine and imaging,Radiation
Cited by
3 articles.
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