Metal-free and regiospecific synthesis of 3-arylindoles-Reference-Cited by-同舟云学术

Metal-free and regiospecific synthesis of 3-arylindoles

Published:2020 Issue:14 Volume:18 Page:2661-2671
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Xu Chuangchuang¹²³⁴⁵^ORCID,Xie Wenlai¹²³⁴⁵,Xu Jiaxi¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Chemical Resource Engineering

2. Department of Organic Chemistry

3. College of Chemistry

4. Beijing University of Chemical Technology

5. Beijing 100029

Abstract

A microwave-assisted acid and base co-catalyzed strategy shows high efficiency in the synthesis of 3-arylindoles through tandem nucleophilic ring-opening and Fischer indolization of aryloxiranecarbonitriles and arylhydrazine hydrochlorides.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00317D

Reference65 articles.

1. Design, synthesis, antitubercular and antiviral properties of new spirocyclic indole derivatives

2. Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors

3. Structural Optimization and Pharmacological Evaluation of Inhibitors Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases (DYRK) and CDC-like kinases (CLK) in Glioblastoma

4. A synthetic 2,3-diarylindole induces cell death via apoptosis and autophagy in A549 lung cancer cells

5. 4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki–Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recent Advances in π-Stacking Interaction-Controlled Asymmetric Synthesis;Molecules;2024-03-24

2. Thiourea-Mediated Stereospecific Deoxygenation of Cyanoepoxides to Access Highly Diastereopure Alkenyl Nitriles;The Journal of Organic Chemistry;2024-01-26

3. Indole frameworks via transition-metal-free annulation: a current perspective;New Journal of Chemistry;2023

4. Synthetic application of oxiranecarbonitriles (microreview);Chemistry of Heterocyclic Compounds;2021-08

5. Direct Synthesis of Indoles from Azoarenes and Ketones with Bis(neopentylglycolato)diboron Using 4,4′-Bipyridyl as an Organocatalyst;The Journal of Organic Chemistry;2021-02-08